Examples of research benefits

Benefits of learning about the liver scavenger cells

My experience is useful to actors who need access to deep knowledge about how the scavenger cells recognise, internalize, and metabolize blood borne large molecules and nano-sized material. The following examples emphasize how such awareness is useful to basic reseacrh and the pharmaceutucal industry.

Example 1:

Development of new generations of large molecule compounds (e.g. proteins and oligo/polynucleotides) and nanoformulations is accelerating due to the possibility they offer to treat diseases that could not previously be cured. A major challenge that needs to be overcome for the successful use of these novel types of pharmaceuticals is to control their clearance by the hepatic scavenger cells. Extensive knowledge about these cells is imperative to understand and suggest remedies to control elimination of blood borne compounds.

Example 2:

Liver diseases are frequently associated with changes in the blood levels of certain body macromolecules. To study the cause and mechanism of this it is common to look for changes in the synthesis of such macromolecules. However, it may equally well be that a decreased liver clearance activity causes this change. A prerequisite to study this possibility is deep knowledge about the activity of the hepatic scavenger cells. 

Example 3:

Successful research applications to fund projects on aspects of hepatic blood clearance activities (e.g. uptake of virus, modified proteins or other potentially harmful substance, interaction of circulatory immune cells with liver cells, etc.) must be based on solid arguments showing that the applicant understands the powerful clearance activity of the liver scavenger cells.